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Updated 12:15 PM September 2, 2008




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Genes may play significant role in nicotine addiction

Anyone who ever has tried smoking probably remembers vividly that first cigarette. For some, it brought a wave of nausea or a nasty coughing fit. For others, the first puffs also came with a rush of pleasure.

A new study links first experiences with smoking and the likelihood that a person currently is a smoker to a particular genetic variation. The finding may help explain the path that leads from a first cigarette to lifelong smoking.

The finding also adds to growing suspicion surrounding the role of a particular nicotine-receptor gene in smoking-related behaviors and in lung cancer. Other researchers already have linked variations in the same genetic region to smokers' level of dependence on nicotine, to the number of cigarettes smoked per day and to a far higher risk of lung cancer — the ultimate outcome of a lifetime of smoking.

In a paper published in the journal Addiction, a multi-university collaborative team of researchers specializing in statistical genetics, gene analysis, and trait analysis reports an association between a variant in the CHRNA5 nicotine receptor gene, initial smoking experiences and current smoking patterns.

The genetic and smoking data come from 435 volunteers. Those who never smoked had tried at least one but no more than 100 cigarettes in their lives and never formed a smoking habit. The regular smokers had at least five cigarettes a day for at least the past five years.

The regular smokers were far more likely than the never-smokers to have the less common rs16969968 form of the CHRNA5 gene, in which just one base-pair in the gene sequence was different from the more common form.

Smokers also were eight times as likely to report that first cigarettes gave them a pleasurable buzz.

"It appears that for people who have a certain genetic makeup, the initial physical reaction to smoking can play a significant role in determining what happens next," says senior author and project leader, Ovide Pomerleau, a professor of psychiatry at the Medical School and founder of the Nicotine Research Laboratory.

"If cigarette smoking is sustained, nicotine addiction can occur in a few days to a few months," he adds.

Sandy Snedecor of the Department of Psychiatry also helped author the paper.

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